How does clinical trial efficacy work (simply put)?

Post date: 2020-12-02 13:05:54
Views: 184
Confused about the data provided on the recent COVID studies, and why they mean vaccines were judged to be 95% effective

The Pfizer and Moderna press releases (Pfizer's linked here) provide three main pieces of data: the number of trial participants, the number of participants who contracted the virus, and the number of participants contracting the virus who were in the control group, receiving a placebo. (Apologies for any mistakes in terminology or anything else I'll be making here.)

So for Pfizer's trial, there were more than 43,000 participants, 170 of them contracting COVID, and 8 of them were in the vaccine group, meaning 162 were in the placebo group. 8/162 is ~5%.

The press releases don't say that this is why the vaccines are judged to be 95% effective, though papers like the Washington Post connect the dots. But how is this not the wrong way to judge effectiveness? Wouldn't the right way be to say 162 out of 16,200, e.g., taking the placebo contracted it, and that's 1%, and 8 of let's say 16,200 receiving the vaccine contracted it, and that's 5% of 1%, meaning the vaccine is 95% effective?
Number of Comments
Please click Here to read the full story.
 
Other Top and Latest Questions:
Disney signals its next CEO will take over a company with strong momentum
AstraZeneca is listing in New York, as Big Pharma balances the huge U.S. market with China's tempting innovation
Housing affordability isn't just hurting buyers: More homeowners are falling behind on their mortgages
Erratic behavior in bitcoin, silver and memory stocks threatens to unnerve bull market
Answered: I'll be taking custom jobs/orders for Q2A
Women say caregiving and child care costs are the No. 1 reason they quit the workforce last year, according to new data
From PopMart to JD.com: Britain and China rush to forge business deals as diplomatic thaw takes hold  
A surprising share of homeowners have high mortgage rates. Here's the breakdown
Amazon makes Alexa+ AI assistant available to everyone in the U.S. nearly a year after launch
Uber reports 20% revenue growth in fourth-quarter, fueled by food delivery