How does clinical trial efficacy work (simply put)?

Post date: 2020-12-02 13:05:54
Views: 228
Confused about the data provided on the recent COVID studies, and why they mean vaccines were judged to be 95% effective

The Pfizer and Moderna press releases (Pfizer's linked here) provide three main pieces of data: the number of trial participants, the number of participants who contracted the virus, and the number of participants contracting the virus who were in the control group, receiving a placebo. (Apologies for any mistakes in terminology or anything else I'll be making here.)

So for Pfizer's trial, there were more than 43,000 participants, 170 of them contracting COVID, and 8 of them were in the vaccine group, meaning 162 were in the placebo group. 8/162 is ~5%.

The press releases don't say that this is why the vaccines are judged to be 95% effective, though papers like the Washington Post connect the dots. But how is this not the wrong way to judge effectiveness? Wouldn't the right way be to say 162 out of 16,200, e.g., taking the placebo contracted it, and that's 1%, and 8 of let's say 16,200 receiving the vaccine contracted it, and that's 5% of 1%, meaning the vaccine is 95% effective?
Number of Comments
Please click Here to read the full story.
 
Other Top and Latest Questions:
Here are the 2 big things we're watching in this week's stock market
Prediction markets are becoming more professionalized, but also harder to beat
Obama voices caution on AI, urges Democrats to tackle it, NYT says
China's Xi urges BRICS nations to work towards peace in the Middle East
Anthropic walks tightrope to Nasdaq, pushing for a slowdown while pursuing $2 trillion valuation
Realistic LSAT practice questions
Trump says U.S. may keep Iranian oil 'like Venezuela' as Gulf-Iran Hormuz talks stall
Cadbury cut two months off its supply chain lead time for a key chocolate-bar ingredient in one move
Z.ai shares tumble over 10% after $5 billion fundraising, its second major raise in two months
In pictures: The U.S. commemorates the 25th anniversary of 9/11